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pentobarbital will reduce the extent or result of fentanyl by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on to a reduce in fentanyl plasma concentrations, deficiency of efficacy or, potentially, growth of a withdrawal syndrome in a cl